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Poster A56, Wednesday, November 8, 10:30 – 11:45 am, Harborview and Loch Raven Ballrooms

Comparing Frontal and Parietal tDCS Montages for Reducing Anomia Symptoms in People with Dementia

Carlos Roncero1, Erik Service1, Alex Thiel1, Stephan Probst1, Howard Chertkow1;1Lady Davis Institute, Jewish General Hospital

INTRODUCTION: We evaluated whether transcranial direct current stimulation (tDCS) in two different montages could improve picture naming abilities in subjects with anomic Alzheimer or frontotemporal dementias. METHODS: Utilizing a double-blind cross-over design, twenty participants were trained on picture naming over a series of 10 sessions with e30 minutes of anodal (2 mA) tDCS stimulation to either the left inferior parieto-temporal region (P3), the left dorsolateral prefrontal cortex (F3), or sham stimulation. We evaluated performance on a trained picture naming list, an equivalent untrained list, and additional neuropsychological tasks. RESULTS: Regardless the montage, participants improved significantly more for trained items when they received real stimulation rather than sham stimulation, lasting at least two weeks post-stimulation. Whereas for the untrained items, improvement was only observed for the P3 montage, compared to a significant decrease when sham stimulation was given. For the F3 montage, there was neither a significant increase nor decrease for untrained items. Finally, as group, participants with semantic dementia showed the least improvement for untrained items. DISCUSSION: tDCS stimulation has promise as a treatment for anomia in demented individuals, but its effectiveness can vary depending on the montage given and participants’ diagnosis.

Topic Area: Language Therapy

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