You are viewing the SNL 2017 Archive Website. For the latest information, see the Current Website.

 
Poster B27, Wednesday, November 8, 3:00 – 4:15 pm, Harborview and Loch Raven Ballrooms

Structural connectivity subserving verbal fluency revealed by lesion-behavior mapping in stroke patients

Mingyang Li1, Yumei Zhang2, Luping Song3, Ruiwang Huang4, Junhua Ding1, Yuxing Fang1, Yangwen Xu1, Zaizhu Han1;1National Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China, 100875, 2Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., 3Rehabilitation College and China Rehabilitation Research Center, Capital Medical University, Beijing, China, 100038., 4Center for the Study of Applied Psychology, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, South China Normal University, Guangzhou, China, 510631.

Tests of verbal fluency have been widely used to assess the cognitive functioning of persons, and are typically classified into two categories (semantic and phonological fluency). While widely-distributed divergent and convergent brain regions have been found to be involved in semantic and phonological fluency, the anatomical connectivity underlying the fluency is not well understood. The present study aims to construct a comprehensive white-matter network associated with semantic and phonological fluency by investigating the relationship between the integrity of 22 major tracts in the whole brain and semantic fluency (measured by 3 cues) and phonological fluency (measured by 2 cues) in a group of 51 stroke patients. We found five left-lateralized tracts including the anterior thalamic radiation (ATR), inferior fronto-occipital fasciculus (IFOF), uncinate fasciculus (UF), superior longitudinal fasciculus (SLF) and frontal aslant tract (FAT) were significantly correlated with the scores of both semantic and phonological fluencies. These effects persisted even when we ruled out the influence of potential confounding factors (e.g., total lesion volume). Moreover, the damage to the first three tracts caused additional impairments in the semantic compared to the phonological fluency. These findings reveal the white-matter neuroanatomical connectivity underlying semantic and phonological fluency, and deepen the understanding of the neural network of verbal fluency.

Topic Area: Language Disorders

Back to Poster Schedule