Slide Slam K2
Extending the reading network: thalamo-cortical connectivity during audio-visual letter-speech sound processing in children with and without developmental dyslexia
Linda Romanovska1, Roef Janssen1, Sonja, A Kotz1, Milene Bonte1; 1Maastricht University
Over the last decades, neuroimaging research has established reduced cortical activation in key brain areas for speech and text processing in dyslexic compared to typical readers. While most of this research has focused on cortical activation and connectivity, much less is known about the contribution of subcortical structures to the reported difficulties in speech and text processing. In this project, we aim to explore functional bilateral thalamo-cortical connectivity patterns in 8-10 year-old children with and without dyslexia using an audio-visual text-speech perception paradigm. Here, children are simultaneously exposed to audio-visual letter-speech sound and meaningless symbol-speech sound pairs in a passive viewing task. We will extract the activity time courses of the bilateral thalami and cortical reading network in response to these audio-visual stimuli and perform a psychophysical interaction (PPI) analysis. Preliminary results indicate differences in connectivity patterns between groups: while dyslexic readers show bilateral thalamo-cortical connectivity, typical readers display a more left-lateralized connectivity pattern in both thalami. A next planned step is to explore potential links between these functional connectivity differences and children’s reading (-related) skills.