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Slide Slam A9

Resting-state functional connectivity following Phonological component analysis: the combined action of phonology and visual orthographic cues

Slide Slam Session A, Tuesday, October 5, 2021, 12:30 - 3:00 pm PDT Log In to set Timezone

Michèle Masson-Trottier1,2, Edith Durand1, Anna Sontheimer3,4,5, Ana Inés Ansaldo1,2; 1Centre de recherche de l'institut universitaire de gériatrie de Montréal (CRIUGM), 2Faculté de Médecine, Université de Montréal, 3Institut Pascal, Université Clermont Auvergne, 4Centre National de la Recherche Scientifique, Institut National Polytechnique-Clermont, 5Centre Hospitalier Universitaire de Clermont-Ferrand

Anomia is the most frequent and pervasive symptom for people with aphasia (PWA). Amongst anomia therapy approaches, phonological component analysis (PCA) is a therapy incorporating phonological cues grounded on models of word processing attributing a key role to the phonological dimensions of noun retrieval. While PCA has been demonstrated effective in English [1, 2], the investigation of neural correlates supporting improvements following PCA remain scarce [2, 3]. Resting-state functional connectivity (rsFC) recovery as a marker of therapy-induced neuroplasticity (TINP)[4] has been previously reported by our team [5, 6]. The present study reports on the efficacy of PCA delivered in French and explores TINP using whole-brain rsFC. Ten PWA participated in a pre-/post-PCA fMRI study. Language and cognitive assessments were completed. A personalized set of stimuli was built based on the naming performance at baseline. PCA was delivered in French in a massed stimulation schedule - three one-hour sessions per week over five weeks - with the following procedure: PWA were asked to generate or choose explicit phonological cues after seeing a picture [1]. Phonological cues were written on the therapy board, as per original therapy design, to assist word retrieval. Wilcoxon signed rank test was performed on naming accuracy scores. fMRI data was preprocessed and analyzed using the CONN toolbox with SPM12. ROI-to-ROI rsFC was calculated as per 132 ROIs in the CONN atlas. PCA led to significant improvement with treated (z=1.988, p=0.047, r=0.629), and untreated (z=2.807, p=0.005, r=0.908) items. A pre-post comparison of rsFC patterns showed an increase in FC between the left anterior temporal fusiform cortex and left supracalcarin cortex (SCC) (T=7.20, pFDR-corrected=0.0053). Also, a decrease in FC between the right lingual gyrus and right superior frontal gyrus (SFG) was observed (T=-5.73, pFDR-corrected=0.0295). The results show that that PCA delivered in French improves word retrieval with treated and untreated words. As for rsFC changes following PCA, the evidence showed an increase in FC between the left anterior temporal fusiform cortex - involved in phonological representation of words in naming [7] and in reading [8], and in orthographic and phonological correspondence [9] - and the left SCC, i.e., the primary visual cortex. Furthermore, there was decrease of rsFC between the right lingual gyrus - involved in semantic and phonological in reading and character recognition [10],- and the right SFG, known for its role in organizing and enacting sequences of speech sounds [11]. As a whole, the rsFC changes can be interpreted within the frame of the visual-phonological nature of PCA. To conclude, behavioral and rsFC data changes associated with intensive administration of PCA to treat anomia in French, highlight the efficacy of PCA, and point to the importance of phonological-orthographic cues for the consolidation of a word-retrieval strategy that contributes to generalization of therapy effects to untreated words [12]. Future studies with a larger sample of participants are required to further explore this avenue. 1.doi.org/10.1080/02687030701831474 2.doi:10.3389/fneur.2018.00225 3.doi:10.1002/hbm.22448 4.doi:10.1016/j.bandc.2017.08.005 5.doi:10.1016/j.bandl.2012.11.004 6.doi:10.1016/j.bandc.2020.105659 7.doi:10.1006/brln.2001.2563 8.doi:10.1002/hbm.20122 9.doi:10.1093/cercor/bhw300 10.doi:10.1016/j.ijpsycho.2012.02.013 11.doi:10.1016/j.bandl.2011.05.010 12.doi:10.1080/02687038.2020.1781419

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