Poster D20, Wednesday, August 21, 2019, 5:15 – 7:00 pm, Restaurant Hall
French version of the Phonological Component Analysis: Preliminary results with nine participants
Michele Masson-Trottier1,2, Karine Marcotte1,3, Carol Leonard4,5,7, Elizabeth Rochon5,6,7, Ana Inés Ansaldo1,2;1Université de Montréal, 2Centre de recherche de l'Institut universitaire de gériatrie de Montréal, 3Centre de recherche de l'Hôpital Sacré-Coeur de Montréal, 4University of Ottawa, 5University of Toronto, 6Toronto Rehabilitation Institute, 7Canadian Partnership for Stroke Recovery, Heart and Stroke Foundation
Introduction. Anomia is the main symptom, and most persistent aphasia sign. Among anomia therapy procedures, Phonological Component Analysis (PCA)[1] has been proven effective in improving the naming capacities of some English-speaking persons with chronic aphasia. PCA uses phonological cues associated with the target word to elicit naming. The present study aims to identify the effects of an adapted French Canadian PCA therapy[2] on the accuracy and response time (RT) of native French speakers with aphasia. Methodology. The present work, part of a larger ongoing study, presents the preliminary results of nine chronic aphasia participants. Participant received 1 hour therapy, 3 times per week for 5 weeks (total of 15 hours). The performance (accuracy and RT- when available) before therapy was compared to the performance after therapy using a related sample – Wilcoxon test. Pre-, post-therapy and 3-month follow-up scores on the Test de Dénomination de Québec: TDQ-60[4] and the DVL-38[5] are used to measure generalization and maintenance. Pre and post functional connectivity (FC) changes during resting state fMRI was also used to study neurofunctional impact of the therapy with five of the nine participants (four were fMRI non-compatible). Preliminary results. At the group level, the therapy was effective at improving accuracy (rate) (from μacc-pre=0.67±0.02 to μacc-post=0.84±0.01, Z=8.776<0.0001) and RT (in seconds) (from μRT-pre=8.00±0.60 to μRT-post=5.84±0.42, Z=-6.219, p=0.012). On the TDQ-60, we observe participants who improve at post-therapy (6/9) and that maintain or continue improving at 3 months post-therapy (3/6). The therapy also significantly increased the FC between the canonical language network[6] and the action observation[7] network as well as decreased the FC between the action observation network[7] and the mental imagery network[7]. Conclusions. The results replicate results obtained in previous work[1], PCA leads to improvements in naming for some aphasic participants. It is important to continue this work to find markers predicting the effectiveness of this therapy. In addition, future studies will examine the neurobiological substrates supporting the effectiveness of PCA. 1 Leonard et al. Aphasiology 22, 923-947, doi:doi.org/10.1080/02687030701831474 (2008). 2 Masson-Trottier et al. in Academy of Aphasia – 55th Annual Meeting, November 5th - 7th 2017 (Baltimore, USA, 2017). 3 Jacqueline et al. Frontiers in Psychology 7, doi:10.3389/conf.fpsyg.2016.68.00113 (2016). 4 Macoir et al. Aging, Neuropsychology, and Cognition, 1-14 (2017). 5 Hammelrath. (Isbergues: Ortho-Édition, 2005). 6 Baldassarre et al. Neurology 92, e125-e135, doi:10.1212/WNL.0000000000006738 (2019). 7 Courson et al. in Tenth Annual Society for the Neurobiology of Language Meeting.
Themes: Disorders: Acquired, Language Therapy
Method: Functional Imaging